6e0a

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Current revision (14:38, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6e0a' size='340' side='right'caption='[[6e0a]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
<StructureSection load='6e0a' size='340' side='right'caption='[[6e0a]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e0a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori_(strain_ss1) Helicobacter pylori (strain ss1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E0A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e0a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_SS1 Helicobacter pylori SS1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E0A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tlpA, HPYLSS1_00094 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=102617 Helicobacter pylori (strain SS1)])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0a OCA], [http://pdbe.org/6e0a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e0a RCSB], [http://www.ebi.ac.uk/pdbsum/6e0a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0a OCA], [https://pdbe.org/6e0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e0a RCSB], [https://www.ebi.ac.uk/pdbsum/6e0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0a ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A1U9IS38_HELPX A0A1U9IS38_HELPX]
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Bacteria use chemoreceptor proteins to sense and navigate their chemical environments. The most common class of chemoreceptors are transmembrane proteins that sense chemical cues through binding of a small molecule ligand to a periplasmic domain, which modulates the receptor's ability to stimulate reversal of the cell's flagella motors. The prevalent gastric pathogen Helicobacter pylori (H. pylori) uses such membrane-bound chemoreceptors, called transducer-like proteins (Tlp), to colonize and persist within the stomach. TlpA has been implicated in sensing arginine, bicarbonate, and acid, but no experimentally determined protein structures of TlpA were available to better understand ligand binding and signal transduction. Here, we report three crystal structures of the periplasmic portion of TlpA, which contains tandem PAS/Cache domains, similar to a recently published structure of the lactate-sensing chemoreceptor TlpC from H. pylori. We performed sequence analyses to identify TlpA and TlpC homologues and used residue conservation amongst these homologues to implicate regions important for the general tandem PAS/Cache fold, and residues specific to TlpA function. Comparisons with TlpC show that despite high similarity across the general structure, TlpA lacks the residues required to bind lactate, and instead contains a pocket almost entirely hydrophobic in nature. This article is protected by copyright. All rights reserved.
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Structures of the Ligand-Binding Domain of Helicobacter pylori Chemoreceptor TlpA.,Sweeney EG, Perkins A, Kallio K, Remington SJ, Guillemin K Protein Sci. 2018 Aug 31. doi: 10.1002/pro.3503. PMID:30171638<ref>PMID:30171638</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6e0a" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Helicobacter pylori SS1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Guillemin, K]]
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[[Category: Guillemin K]]
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[[Category: Perkins, A]]
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[[Category: Perkins A]]
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[[Category: Remington, S J]]
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[[Category: Remington SJ]]
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[[Category: Sweeney, E]]
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[[Category: Sweeney E]]
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[[Category: Chemoreceptor]]
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[[Category: Helix bundle]]
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[[Category: Pas/cache]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of Helicobacter pylori TlpA Chemoreceptor Ligand Binding Domain

PDB ID 6e0a

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