6e8g

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Current revision (14:39, 13 March 2024) (edit) (undo)
 
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<SX load='6e8g' size='340' side='right' viewer='molstar' caption='[[6e8g]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<SX load='6e8g' size='340' side='right' viewer='molstar' caption='[[6e8g]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e8g]] is a 72 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E8G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6E8G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e8g]] is a 72 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E8G FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IST1, KIAA0174 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CHMP1B, C18orf2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6e8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e8g OCA], [http://pdbe.org/6e8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e8g RCSB], [http://www.ebi.ac.uk/pdbsum/6e8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e8g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e8g OCA], [https://pdbe.org/6e8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e8g RCSB], [https://www.ebi.ac.uk/pdbsum/6e8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e8g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN]] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref> [[http://www.uniprot.org/uniprot/CHM1B_HUMAN CHM1B_HUMAN]] Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.<ref>PMID:14519844</ref> <ref>PMID:19129479</ref>
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[https://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref>
==See Also==
==See Also==
*[[Charged multivesicular body protein 3D structures|Charged multivesicular body protein 3D structures]]
*[[Charged multivesicular body protein 3D structures|Charged multivesicular body protein 3D structures]]
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*[[Increased sodium tolerance protein|Increased sodium tolerance protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Frost, A]]
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[[Category: Frost A]]
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[[Category: McCullough, J]]
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[[Category: McCullough J]]
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[[Category: Talledge, N]]
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[[Category: Talledge N]]
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[[Category: Chmp1b]]
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[[Category: Dna binding protein]]
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[[Category: Escrt-iii]]
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[[Category: Ist1]]
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[[Category: Protein fibril]]
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[[Category: Ssdna]]
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Current revision

CryoEM reconstruction of IST1-CHMP1B copolymer filament bound to ssDNA at 2.9 Angstrom resolution

6e8g, resolution 2.90Å

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