6m8h
From Proteopedia
(Difference between revisions)
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<StructureSection load='6m8h' size='340' side='right'caption='[[6m8h]], [[Resolution|resolution]] 2.07Å' scene=''> | <StructureSection load='6m8h' size='340' side='right'caption='[[6m8h]], [[Resolution|resolution]] 2.07Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6m8h]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6m8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M8H FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8h OCA], [https://pdbe.org/6m8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m8h RCSB], [https://www.ebi.ac.uk/pdbsum/6m8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8h ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ballicora | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Goossens | + | [[Category: Ballicora M]] |
| - | [[Category: Kothawala | + | [[Category: Goossens J]] |
| - | [[Category: Leverson | + | [[Category: Kothawala S]] |
| - | [[Category: Liu | + | [[Category: Leverson B]] |
| - | [[Category: Mascarenhas | + | [[Category: Liu D]] |
| - | [[Category: Olsen | + | [[Category: Mascarenhas R]] |
| - | [[Category: | + | [[Category: Olsen K]] |
| - | + | [[Category: De freitas D]] | |
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Current revision
Crystal Structure of the R208Q mutant of G(i) subunit alpha-1
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