6n40

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Current revision (14:46, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6n40' size='340' side='right'caption='[[6n40]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
<StructureSection load='6n40' size='340' side='right'caption='[[6n40]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6n40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N40 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6n40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N40 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6n3t|6n3t]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.307&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MSMEG_0250 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n40 OCA], [https://pdbe.org/6n40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n40 RCSB], [https://www.ebi.ac.uk/pdbsum/6n40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n40 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n40 OCA], [https://pdbe.org/6n40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n40 RCSB], [https://www.ebi.ac.uk/pdbsum/6n40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n40 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMPL3_MYCS2 MMPL3_MYCS2] Transports trehalose monomycolate (TMM) to the cell wall (PubMed:31239378, PubMed:22520756, PubMed:28698380). Flips TMM across the inner membrane. Membrane potential is not required for this function (PubMed:28698380). Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) (PubMed:31113875). Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness (PubMed:28703701).<ref>PMID:22520756</ref> <ref>PMID:28698380</ref> <ref>PMID:28703701</ref> <ref>PMID:31113875</ref> <ref>PMID:31239378</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mycs2]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Su, C C]]
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[[Category: Su C-C]]
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[[Category: Antibiotic]]
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[[Category: Membrane protein]]
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[[Category: Transporter]]
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Current revision

Crystal structure of MmpL3 from Mycobacterium smegmatis

PDB ID 6n40

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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