6nl4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine== | |
| + | <StructureSection load='6nl4' size='340' side='right'caption='[[6nl4]], [[Resolution|resolution]] 1.99Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6nl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NL4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.991Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GEO:GEMCITABINE'>GEO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nl4 OCA], [https://pdbe.org/6nl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nl4 RCSB], [https://www.ebi.ac.uk/pdbsum/6nl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nl4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Dethiobiotin synthetase 3D structures|Dethiobiotin synthetase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Bruning | + | </StructureSection> |
| - | [[Category: Thompson | + | [[Category: Large Structures]] |
| - | [[Category: Wegener | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| + | [[Category: Bruning JB]] | ||
| + | [[Category: Polyak SW]] | ||
| + | [[Category: Thompson AP]] | ||
| + | [[Category: Wegener KL]] | ||
Current revision
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine
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