6p7t

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Current revision (14:54, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6p7t' size='340' side='right'caption='[[6p7t]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='6p7t' size='340' side='right'caption='[[6p7t]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6p7t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P7T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6p7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P7T FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6p7r|6p7r]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p7t OCA], [http://pdbe.org/6p7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p7t RCSB], [http://www.ebi.ac.uk/pdbsum/6p7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p7t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p7t OCA], [https://pdbe.org/6p7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p7t RCSB], [https://www.ebi.ac.uk/pdbsum/6p7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p7t ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9F5Q9_VIBCL Q9F5Q9_VIBCL]
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The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of Vibrio cholerae, the gram-negative bacterial pathogen that causes the diarrheal disease cholera. Unsaturated fatty acids (UFAs) found in bile inhibit the activity of ToxT. Crystal structures of inhibited ToxT bound to UFA or synthetic inhibitors have been reported, but no structure of ToxT in an active conformation had been determined. Here we present the 2.5 A structure of ToxT without an inhibitor. The structure suggests release of UFA or inhibitor leads to an increase in flexibility, allowing ToxT to adopt an active conformation that is able to dimerize and bind DNA. Small-angle X-ray scattering was used to validate a structural model of an open ToxT dimer bound to the cholera toxin promoter. The results presented here provide a detailed structural mechanism for virulence gene regulation in V. cholerae by the UFA components of bile and other synthetic ToxT inhibitors.
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Structural basis for virulence regulation in Vibrio cholerae by unsaturated fatty acid components of bile.,Cruite JT, Kovacikova G, Clark KA, Woodbrey AK, Skorupski K, Kull FJ Commun Biol. 2019 Nov 28;2:440. doi: 10.1038/s42003-019-0686-x. eCollection 2019. PMID:31815195<ref>PMID:31815195</ref>
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==See Also==
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*[[ToxT|ToxT]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6p7t" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cruite, J T]]
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[[Category: Vibrio cholerae]]
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[[Category: Kull, F J]]
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[[Category: Cruite JT]]
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[[Category: Arac]]
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[[Category: Kull FJ]]
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[[Category: Cholerae]]
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[[Category: Dna binding protein]]
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[[Category: Virulence regulation]]
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[[Category: Xyl]]
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Current revision

Crystal structure of apo ToxT K231A from Vibrio cholerae strain SCE256

PDB ID 6p7t

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