6pfj

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<StructureSection load='6pfj' size='340' side='right'caption='[[6pfj]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
<StructureSection load='6pfj' size='340' side='right'caption='[[6pfj]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pfj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strvp Strvp] and [http://en.wikipedia.org/wiki/Streptomyces_sp._pansc19 Streptomyces sp. pansc19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PFJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pfj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._PanSC19 Streptomyces sp. PanSC19] and [https://en.wikipedia.org/wiki/Streptomyces_venezuelae_ATCC_10712 Streptomyces venezuelae ATCC 10712]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PFJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SVEN_3933 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=953739 STRVP]), EDD98_3685 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1520455 Streptomyces sp. PanSC19])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfj OCA], [http://pdbe.org/6pfj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pfj RCSB], [http://www.ebi.ac.uk/pdbsum/6pfj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pfj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfj OCA], [https://pdbe.org/6pfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pfj RCSB], [https://www.ebi.ac.uk/pdbsum/6pfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pfj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A3N1Q704_9ACTN A0A3N1Q704_9ACTN]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.[RuleBase:RU362124]
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[https://www.uniprot.org/uniprot/F2RFR7_STRVP F2RFR7_STRVP]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptomyces are our primary source of antibiotics, produced concomitantly with the transition from vegetative growth to sporulation in a complex developmental life cycle. We previously showed that the signaling molecule c-di-GMP binds BldD, a master repressor, to control initiation of development. Here we demonstrate that c-di-GMP also intervenes later in development to control differentiation of the reproductive hyphae into spores by arming a novel anti-sigma (RsiG) to bind and sequester a sporulation-specific sigma factor (sigma(WhiG)). We present the structure of the RsiG-(c-di-GMP)2-sigma(WhiG) complex, revealing an unusual, partially intercalated c-di-GMP dimer bound at the RsiG-sigma(WhiG) interface. RsiG binds c-di-GMP in the absence of sigma(WhiG), employing a novel E(X)3S(X)2R(X)3Q(X)3D motif repeated on each helix of a coiled coil. Further studies demonstrate that c-di-GMP is essential for RsiG to inhibit sigma(WhiG). These findings reveal a newly described control mechanism for sigma-anti-sigma complex formation and establish c-di-GMP as the central integrator of Streptomyces development.
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c-di-GMP Arms an Anti-sigma to Control Progression of Multicellular Differentiation in Streptomyces.,Gallagher KA, Schumacher MA, Bush MJ, Bibb MJ, Chandra G, Holmes NA, Zeng W, Henderson M, Zhang H, Findlay KC, Brennan RG, Buttner MJ Mol Cell. 2019 Nov 27. pii: S1097-2765(19)30835-4. doi:, 10.1016/j.molcel.2019.11.006. PMID:31810759<ref>PMID:31810759</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6pfj" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Sigma factor 3D structures|Sigma factor 3D structures]]
*[[Sigma factor 3D structures|Sigma factor 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Streptomyces sp. pansc19]]
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[[Category: Streptomyces sp. PanSC19]]
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[[Category: Strvp]]
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[[Category: Streptomyces venezuelae ATCC 10712]]
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[[Category: Schumacher, M A]]
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[[Category: Schumacher MA]]
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[[Category: Anti-sigma]]
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[[Category: C-di-gmp]]
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[[Category: Developmental switch]]
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[[Category: Sigma]]
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[[Category: Transcription]]
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Current revision

Structure of S. venezuelae RsiG-WhiG-(ci-di-GMP) complex, P64 crystal form

PDB ID 6pfj

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