1qz7

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[[Image:1qz7.gif|left|200px]]
[[Image:1qz7.gif|left|200px]]
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{{Structure
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|PDB= 1qz7 |SIZE=350|CAPTION= <scene name='initialview01'>1qz7</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1qz7", creates the "Structure Box" on the page.
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|GENE= CTNNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), AXIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])
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{{STRUCTURE_1qz7| PDB=1qz7 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz7 OCA], [http://www.ebi.ac.uk/pdbsum/1qz7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qz7 RCSB]</span>
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'''Beta-catenin binding domain of Axin in complex with beta-catenin'''
'''Beta-catenin binding domain of Axin in complex with beta-catenin'''
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[[Category: Xing, Y.]]
[[Category: Xing, Y.]]
[[Category: Xu, W.]]
[[Category: Xu, W.]]
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[[Category: axin]]
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[[Category: Axin]]
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[[Category: beta-catenin]]
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[[Category: Beta-catenin]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:53:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:03 2008''
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Revision as of 03:53, 3 May 2008

Image:1qz7.gif

Template:STRUCTURE 1qz7

Beta-catenin binding domain of Axin in complex with beta-catenin


Contents

Overview

The "beta-catenin destruction complex" is central to canonical Wnt/beta-catenin signaling. The scaffolding protein Axin and the tumor suppressor adenomatous polyposis coli protein (APC) are critical components of this complex, required for rapid beta-catenin turnover. We determined the crystal structure of a complex between beta-catenin and the beta-catenin-binding domain of Axin (Axin-CBD). The Axin-CBD forms a helix that occupies the groove formed by the third and fourth armadillo repeats of beta-catenin and thus precludes the simultaneous binding of other beta-catenin partners in this region. Our biochemical studies demonstrate that, when phosphorylated, the 20-amino acid repeat region of APC competes with Axin for binding to beta-catenin. We propose that a key function of APC in the beta-catenin destruction complex is to remove phosphorylated beta-catenin product from the active site.

Disease

Known disease associated with this structure: Colorectal cancer OMIM:[116806], Hepatoblastoma OMIM:[116806], Hepatocellular carcinoma OMIM:[116806], Ovarian carcinoma, endometrioid type OMIM:[116806], Pilomatricoma OMIM:[116806]

About this Structure

1QZ7 is a Protein complex structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex., Xing Y, Clements WK, Kimelman D, Xu W, Genes Dev. 2003 Nov 15;17(22):2753-64. Epub 2003 Nov 4. PMID:14600025 Page seeded by OCA on Sat May 3 06:53:02 2008

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