6up5

<StructureSection load='6up5' size='340' side='right'caption='[[6up5]], [[Resolution|resolution]] 1.92&Aring;' scene=''>

<table><tr><td colspan='2'>[[6up5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UP5 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6up5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6up5 OCA], [https://pdbe.org/6up5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6up5 RCSB], [https://www.ebi.ac.uk/pdbsum/6up5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6up5 ProSAT]</span></td></tr>

== Disease ==

[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.

== Function ==

[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]

==See Also==

*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]

[[Category: Homo sapiens]]