1qzu

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[[Image:1qzu.jpg|left|200px]]
[[Image:1qzu.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1qzu |SIZE=350|CAPTION= <scene name='initialview01'>1qzu</scene>, resolution 2.91&Aring;
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The line below this paragraph, containing "STRUCTURE_1qzu", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphopantothenoylcysteine_decarboxylase Phosphopantothenoylcysteine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.36 4.1.1.36] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= coac ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1qzu| PDB=1qzu | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qzu OCA], [http://www.ebi.ac.uk/pdbsum/1qzu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qzu RCSB]</span>
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}}
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'''crystal structure of human phosphopantothenoylcysteine decarboxylase'''
'''crystal structure of human phosphopantothenoylcysteine decarboxylase'''
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[[Category: Ealick, S E.]]
[[Category: Ealick, S E.]]
[[Category: Manoj, N.]]
[[Category: Manoj, N.]]
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[[Category: alpha-beta sandwich]]
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[[Category: Alpha-beta sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:54:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:15 2008''
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Revision as of 03:54, 3 May 2008

Image:1qzu.jpg

Template:STRUCTURE 1qzu

crystal structure of human phosphopantothenoylcysteine decarboxylase


Overview

Phosphopantothenoylcysteine (PPC) decarboxylase is an essential enzyme in the biosynthesis of coenzyme A and catalyzes the decarboxylation of PPC to phosphopantetheine. Human PPC decarboxylase has been expressed in Escherichia coli, purified and crystallized. The Laue class of the diffraction data appears to be 3m, suggesting space group R32 with two monomers per asymmetric unit. However, the crystals belong to the space group R3 and the asymmetric unit contains four monomers. The structure has been solved using molecular replacement and refined to a current R factor of 29%. The crystal packing can be considered as two interlaced lattices, each consistent with space group R32 and with the corresponding twofold axes parallel to each other but separated along the threefold axis. Thus, the true space group is R3 with four monomers per asymmetric unit.

About this Structure

1QZU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase., Manoj N, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1762-6. Epub 2003, Sep 19. PMID:14501115 Page seeded by OCA on Sat May 3 06:54:17 2008

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OCA

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