1b6e

<table><tr><td colspan='2'>[[1b6e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B6E FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b6e OCA], [https://pdbe.org/1b6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b6e RCSB], [https://www.ebi.ac.uk/pdbsum/1b6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b6e ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/KLRD1_HUMAN KLRD1_HUMAN]] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

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== Publication Abstract from PubMed ==

The crystal structure of the extracellular domain of CD94, a component of the CD94/NKG2 NK cell receptor, has been determined to 2.6 A resolution, revealing a unique variation of the C-type lectin fold. In this variation, the second alpha helix, corresponding to residues 102-112, is replaced by a loop, the putative carbohydrate-binding site is significantly altered, and the Ca2+-binding site appears nonfunctional. This structure may serve as a prototype for other NK cell receptors such as Ly-49, NKR-P1, and CD69. The CD94 dimer observed in the crystal has an extensive hydrophobic interface that stabilizes the loop conformation of residues 102-112. The formation of this dimer reveals a putative ligand-binding region for HLA-E and suggests how NKG2 interacts with CD94.

Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors.,Boyington JC, Riaz AN, Patamawenu A, Coligan JE, Brooks AG, Sun PD Immunity. 1999 Jan;10(1):75-82. PMID:10023772<ref>PMID:10023772</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Boyington, J C]]

[[Category: Brooks, A G]]

[[Category: Coligan, J E]]

[[Category: Patamawenu, A]]

[[Category: Riaz, A N]]

[[Category: Sun, P D]]

[[Category: Receptor]]