1agj
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(New page: 200px<br /> <applet load="1agj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1agj, resolution 1.7Å" /> '''EPIDERMOLYTIC TOXIN ...)
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Revision as of 16:26, 29 October 2007
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EPIDERMOLYTIC TOXIN A FROM STAPHYLOCOCCUS AUREUS
Overview
BACKGROUND: Staphylococcal epidermolytic toxins A and B (ETA and ETB) are, responsible for the staphylococcal scalded skin syndrome of newborn and, young infants; this condition can appear just a few hours after birth., These toxins cause the disorganization and disruption of the region, between the stratum spinosum and the stratum granulosum--two of the three, cellular layers constituting the epidermis. The physiological substrate of, ETA is not known and, consequently, its mode of action in vivo remains an, unanswered question. Determination of the structure of ETA and its, comparison with other serine proteases may reveal insights into ETA's, catalytic mechanism. RESULTS: The crystal structure of staphylococcal ETA, has been determined by multiple isomorphous replacement and refined at ... [(full description)]
About this Structure
1AGJ is a [Single protein] structure of sequence from [Staphylococcus aureus]. Full crystallographic information is available from [OCA].
Reference
The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7 A resolution., Cavarelli J, Prevost G, Bourguet W, Moulinier L, Chevrier B, Delagoutte B, Bilwes A, Mourey L, Rifai S, Piemont Y, Moras D, Structure. 1997 Jun 15;5(6):813-24. PMID:9261066
Page seeded by OCA on Mon Oct 29 18:31:20 2007
