1bti

<table><tr><td colspan='2'>[[1bti]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BTI FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bti OCA], [https://pdbe.org/1bti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bti RCSB], [https://www.ebi.ac.uk/pdbsum/1bti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bti ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.

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== Publication Abstract from PubMed ==

Crystal structures of four mutants of bovine pancreatic trypsin inhibitor (F22A, Y23A, N43G, and F45A), engineered to alter their stability properties, have been determined. The mutated residues, which are highly conserved among Kunitz-type inhibitors, are located in the rigid core of the molecule. Replacement of the partially buried bulky residues of the wild-type protein with smaller residues resulted in crevices open to the exterior of the molecule. The overall three-dimensional structure of these mutants is very similar to that of the wild-type protein and only small rearrangements are observed among the atoms lining the crevices.

 

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== References ==

[[Category: Fuchs, J]]

[[Category: Housset, D]]

[[Category: Kim, K S]]

[[Category: Tao, F]]

[[Category: Wlodawer, A]]

[[Category: Woodward, C]]

[[Category: Serine protease inhibitor]]