1btv

<StructureSection load='1btv' size='340' side='right'caption='[[1btv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1btv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betpn Betpn]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BTV FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1btv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1btv OCA], [https://pdbe.org/1btv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1btv RCSB], [https://www.ebi.ac.uk/pdbsum/1btv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1btv ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity).

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== Publication Abstract from PubMed ==

The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.

X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy.,Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858<ref>PMID:8946858</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1btv" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Betpn]]

[[Category: Gajhede, M]]

[[Category: Larsen, J N]]

[[Category: Osmark, P]]

[[Category: Poulsen, F M]]

[[Category: Spangfort, M D]]

[[Category: Pr-10 protein]]