1buz

<StructureSection load='1buz' size='340' side='right'caption='[[1buz]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1buz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1BUZ FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPOIIAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1buz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1buz OCA], [http://pdbe.org/1buz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1buz RCSB], [http://www.ebi.ac.uk/pdbsum/1buz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1buz ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/SP2AA_BACSU SP2AA_BACSU]] In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.<ref>PMID:8358793</ref>

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== Publication Abstract from PubMed ==

The establishment of differential gene expression in sporulating Bacillus subtilis involves four protein components, one of which, SpoIIAA, undergoes phosphorylation and dephosphorylation. We have used NMR spectroscopy to determine the solution structure of the nonphosphorylated form of SpoIIAA. The structure shows a fold consisting of a four-stranded beta-sheet and four alpha-helices. Knowledge of the structure helps to account for the phenotype of several strains of B. subtilis that carry known spoIIAA mutations and should facilitate investigations of the conformational consequences of phosphorylation.

Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor sigmaF of Bacillus subtilis.,Kovacs H, Comfort D, Lord M, Campbell ID, Yudkin MD Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5067-71. PMID:9560229<ref>PMID:9560229</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1buz" style="background-color:#fffaf0;"></div>

[[Category: Vibrio subtilis ehrenberg 1835]]

[[Category: Campbell, I D]]

[[Category: Comfort, D]]

[[Category: Kovacs, H]]

[[Category: Lord, M]]

[[Category: Yudkin, M D]]

[[Category: Transcription regulator]]