1r0d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1r0d.gif|left|200px]]
[[Image:1r0d.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1r0d |SIZE=350|CAPTION= <scene name='initialview01'>1r0d</scene>, resolution 1.90&Aring;
+
The line below this paragraph, containing "STRUCTURE_1r0d", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= HIP1R, HIP12, KIAA0655 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01608 I_LWEQ]</span>
+
{{STRUCTURE_1r0d| PDB=1r0d | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0d OCA], [http://www.ebi.ac.uk/pdbsum/1r0d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r0d RCSB]</span>
+
-
}}
+
'''HIP1R THATCH DOMAIN CORE'''
'''HIP1R THATCH DOMAIN CORE'''
Line 28: Line 25:
[[Category: Fremont, D H.]]
[[Category: Fremont, D H.]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
-
[[Category: actin-binding]]
+
[[Category: Actin-binding]]
-
[[Category: endocytosis]]
+
[[Category: Endocytosis]]
-
[[Category: mcsg]]
+
[[Category: Mcsg]]
-
[[Category: midwest center for structural genomic]]
+
[[Category: Midwest center for structural genomic]]
-
[[Category: protein structure initiative]]
+
[[Category: Protein structure initiative]]
-
[[Category: psi]]
+
[[Category: Psi]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:55:05 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:26 2008''
+

Revision as of 03:55, 3 May 2008

Image:1r0d.gif

Template:STRUCTURE 1r0d

HIP1R THATCH DOMAIN CORE


Overview

Huntingtin-interacting protein-1 related (HIP1R) has a crucial protein-trafficking role, mediating associations between actin and clathrin-coated structures at the plasma membrane and trans-Golgi network. Here, we characterize the F-actin-binding region of HIP1R, termed the talin-HIP1/R/Sla2p actin-tethering C-terminal homology (THATCH) domain. The 1.9-A crystal structure of the human HIP1R THATCH core reveals a large sequence-conserved surface patch created primarily by residues from the third and fourth helices of a unique five-helix bundle. Point mutations of seven contiguous patch residues produced significant decreases in F-actin binding. We also show that THATCH domains have a conserved C-terminal latch capable of oligomerizing the core, thereby modulating F-actin engagement. Collectively, these results establish a framework for investigating the links between endocytosis and actin dynamics mediated by THATCH domain-containing proteins.

About this Structure

1R0D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural definition of the F-actin-binding THATCH domain from HIP1R., Brett TJ, Legendre-Guillemin V, McPherson PS, Fremont DH, Nat Struct Mol Biol. 2006 Feb;13(2):121-30. Epub 2006 Jan 15. PMID:16415883 Page seeded by OCA on Sat May 3 06:55:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r0d"
Personal tools