1r0c

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[[Image:1r0c.jpg|left|200px]]
[[Image:1r0c.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1r0c |SIZE=350|CAPTION= <scene name='initialview01'>1r0c</scene>, resolution 2.37&Aring;
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The line below this paragraph, containing "STRUCTURE_1r0c", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NCD:N-CARBAMOYL-L-ASPARTATE'>NCD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_carbamoyltransferase Aspartate carbamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.2 2.1.3.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PYRB OR B4245 OR C5345 OR Z5856 OR ECS5222 OR SF4245 OR S4507 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), PYRI OR B4244 OR C5344 OR Z5855 OR ECS5221 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1r0c| PDB=1r0c | SCENE= }}
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|RELATEDENTRY=[[1r0b|1R0B]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0c OCA], [http://www.ebi.ac.uk/pdbsum/1r0c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r0c RCSB]</span>
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}}
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'''Products in the T State of Aspartate Transcarbamylase: Crystal Structure of the Phosphate and N-carbamyl-L-aspartate Ligated Enzyme'''
'''Products in the T State of Aspartate Transcarbamylase: Crystal Structure of the Phosphate and N-carbamyl-L-aspartate Ligated Enzyme'''
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[[Category: Huang, J.]]
[[Category: Huang, J.]]
[[Category: Lipscomb, W N.]]
[[Category: Lipscomb, W N.]]
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[[Category: aspartate carbamoyltransferase]]
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[[Category: Aspartate carbamoyltransferase]]
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[[Category: aspartate transcarbamylase]]
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[[Category: Aspartate transcarbamylase]]
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[[Category: atcase-products complex]]
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[[Category: Atcase-products complex]]
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[[Category: n-carbamyl-l-aspartate(cla)]]
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[[Category: Phosphate]]
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[[Category: phosphate]]
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[[Category: Product]]
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[[Category: product]]
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[[Category: T state]]
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[[Category: t state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:55:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:27 2008''
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Revision as of 03:55, 3 May 2008

Image:1r0c.jpg

Template:STRUCTURE 1r0c

Products in the T State of Aspartate Transcarbamylase: Crystal Structure of the Phosphate and N-carbamyl-L-aspartate Ligated Enzyme


Overview

The structure of aspartate transcarbamylase of Escherichia coli ligated to products (phosphate and N-carbamyl-l-aspartate) has been determined at 2.37 A resolution (R-factor = 0.23, R(free) = 0.27). Results might indicate a product release mode, rather than close analogues to the transition state like those found in our earlier studies of other ligands (N-phosphonacetyl-L-aspartate, carbamyl phosphate plus malonate, phosphonoacetamide plus malonate, or citrate plus phosphate). Ordered product release, first carbamylaspartate (CLA) and then phosphate, might be facilitated by a 4 A movement of phosphate from the substrate-analogue position to the product (phosphate) binding position, and by a somewhat similar release movement of the other product (CLA) relative to its analogue (citrate). This movement is consistent with earlier studies of binding of either pyrophosphate or phosphate alone [Honzatko, R. B., and Lipscomb, W. N. (1982) J. Mol. Biol. 160, 265-286].

About this Structure

1R0C is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Products in the T-state of aspartate transcarbamylase: crystal structure of the phosphate and N-carbamyl-L-aspartate ligated enzyme., Huang J, Lipscomb WN, Biochemistry. 2004 Jun 1;43(21):6422-6. PMID:15157076 Page seeded by OCA on Sat May 3 06:55:08 2008

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