1cq3

<table><tr><td colspan='2'>[[1cq3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpx Cowpx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CQ3 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cq3 OCA], [https://pdbe.org/1cq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1cq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cq3 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses as anti-inflammatory agents. We have determined the crystal structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence factor. The molecule is a beta-sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta-sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.

Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus.,Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:10535930<ref>PMID:10535930</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1cq3" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Cowpx]]

[[Category: Carfi, A]]

[[Category: McGrew, J]]

[[Category: Smith, C A]]

[[Category: Smolak, P J]]

[[Category: Wiley, D C]]

[[Category: Cytokine]]