8c3u
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist== | |
| - | + | <StructureSection load='8c3u' size='340' side='right'caption='[[8c3u]], [[Resolution|resolution]] 1.94Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8c3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C3U FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.945Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T9C:(S)-4-hydroxy-3-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1-biphenyl]-2,4-dicarboxylic+acid'>T9C</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c3u OCA], [https://pdbe.org/8c3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c3u RCSB], [https://www.ebi.ac.uk/pdbsum/8c3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c3u ProSAT]</span></td></tr> |
| - | [[Category: Koch | + | </table> |
| - | [[Category: Rondeau | + | == Function == |
| + | [https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Koch E]] | ||
| + | [[Category: Lehmann S]] | ||
| + | [[Category: Rondeau J-M]] | ||
Current revision
Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist
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