8fx5

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'''Unreleased structure'''
 
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The entry 8fx5 is ON HOLD until 2025-01-23
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==Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline==
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<StructureSection load='8fx5' size='340' side='right'caption='[[8fx5]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fx5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FX5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XNO:xanomeline'>XNO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fx5 OCA], [https://pdbe.org/8fx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fx5 RCSB], [https://www.ebi.ac.uk/pdbsum/8fx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fx5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
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Authors: Vuckovic, Z., Mobbs, J.I., Glukhova, A., Sexton, P.M., Danev, R., Thal, D.M.
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==See Also==
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*[[Transducin 3D structures|Transducin 3D structures]]
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Description: Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Thal, D.M]]
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[[Category: Homo sapiens]]
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[[Category: Mobbs, J.I]]
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[[Category: Large Structures]]
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[[Category: Vuckovic, Z]]
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[[Category: Mus musculus]]
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[[Category: Sexton, P.M]]
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[[Category: Danev R]]
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[[Category: Glukhova, A]]
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[[Category: Glukhova A]]
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[[Category: Danev, R]]
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[[Category: Mobbs JI]]
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[[Category: Sexton PM]]
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[[Category: Thal DM]]
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[[Category: Vuckovic Z]]

Revision as of 11:15, 14 March 2024

Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline

PDB ID 8fx5

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