3qdx

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QDX FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Boletus_edulis Boletus edulis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QDX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qds|3qds]], [[3qdt|3qdt]], [[3qdu|3qdu]], [[3qdw|3qdw]], [[3qdv|3qdv]], [[3qdy|3qdy]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [https://pdbe.org/3qdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [https://www.ebi.ac.uk/pdbsum/3qdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdx OCA], [https://pdbe.org/3qdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qdx RCSB], [https://www.ebi.ac.uk/pdbsum/3qdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdx ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/BEL_BOLED BEL_BOLED]
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A novel lectin has been isolated from the fruiting bodies of the common edible mushroom Boletus edulis (king bolete, penny bun, porcino, or cep) by affinity chromatography on a chitin column. We propose for the lectin the name BEL (Boletus edulis lectin). BEL inhibits selectively the proliferation of several malignant cell lines and binds the neoplastic cell specific T-antigen disaccharide, Galbeta1-3GalNAc. The lectin was structurally characterized: the molecule is a homotetramer and the 142 amino acid sequence of the chains was determined. The protein belongs to the saline-soluble family of mushroom fruiting body specific lectins. BEL was also crystallized and its three-dimensional structure was determined by X-ray diffraction to 1.15 A resolution. The structure is similar to that of Agaricus bisporus lectin. Using the appropriate co-crystals, the interactions of BEL with specific mono and disaccharides were also studied by X-ray diffraction. The six structures of carbohydrate complexes reported here provide details of the interactions of the ligands with the lectin and shed light on the selectivity of the two distinct binding sites present in each protomer.
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STRUCTURE OF A LECTIN WITH ANTITUMORAL PROPERTIES IN KING BOLETE (Boletus edulis) MUSHROOMS.,Bovi M, Carrizo ME, Capaldi S, Perduca M, Chiarelli LR, Galliano M, Monaco HL Glycobiology. 2011 Feb 8. PMID:21303815<ref>PMID:21303815</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qdx" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Boletus edulis]]
[[Category: Boletus edulis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bovi, M]]
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[[Category: Bovi M]]
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[[Category: Capaldi, S]]
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[[Category: Capaldi S]]
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[[Category: Carrizo, M E]]
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[[Category: Carrizo ME]]
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[[Category: Chiarelli, L R]]
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[[Category: Chiarelli LR]]
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[[Category: Galliano, M]]
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[[Category: Galliano M]]
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[[Category: Monaco, H L]]
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[[Category: Monaco HL]]
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[[Category: Perduca, M]]
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[[Category: Perduca M]]
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[[Category: Boletus eduli]]
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[[Category: Carbohydrate]]
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[[Category: Lectin]]
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[[Category: Mushroom]]
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[[Category: N-diacetyl chitobiose]]
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[[Category: Sugar binding]]
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[[Category: Sugar binding protein]]
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[[Category: T-antigen disaccharide]]
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Revision as of 11:42, 14 March 2024

Structure of the orthorhombic form of the Boletus edulis lectin in complex with T-antigen disaccharide and N,N-diacetyl chitobiose

PDB ID 3qdx

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