3qiw

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<StructureSection load='3qiw' size='340' side='right'caption='[[3qiw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='3qiw' size='340' side='right'caption='[[3qiw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qiw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Carolina_sphinx Carolina sphinx] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QIW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qiw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QIW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-Eb1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qiw OCA], [https://pdbe.org/3qiw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qiw RCSB], [https://www.ebi.ac.uk/pdbsum/3qiw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qiw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qiw OCA], [https://pdbe.org/3qiw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qiw RCSB], [https://www.ebi.ac.uk/pdbsum/3qiw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qiw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CYC_MANSE CYC_MANSE]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
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[https://www.uniprot.org/uniprot/HA22_MOUSE HA22_MOUSE]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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T cells specific for the cytochrome c Ag are widely used to investigate many aspects of TCR specificity and interactions with peptide-MHC, but structural information has long been elusive. In this study, we present structures for the well-studied 2B4 TCR, as well as a naturally occurring variant of the 5c.c7 TCR, 226, which is cross-reactive with more than half of possible substitutions at all three TCR-sensitive residues on the peptide Ag. These structures alone and in complex with peptide-MHC ligands allow us to reassess many prior mutagenesis results. In addition, the structure of 226 bound to one peptide variant, p5E, shows major changes in the CDR3 contacts compared with wild-type, yet the TCR V-region contacts with MHC are conserved. These and other data illustrate the ability of TCRs to accommodate large variations in CDR3 structure and peptide contacts within the constraints of highly conserved TCR-MHC interactions.
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Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-E.,Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin AE, Kuhns MS, Garcia KC, Davis MM J Immunol. 2011 Apr 13. PMID:21490152<ref>PMID:21490152</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qiw" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
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== References ==
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*[[MHC II 3D structures|MHC II 3D structures]]
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carolina sphinx]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Manduca sexta]]
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[[Category: Davis, M M]]
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[[Category: Mus musculus]]
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[[Category: Ely, L K]]
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[[Category: Davis MM]]
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[[Category: Garcia, K C]]
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[[Category: Ely LK]]
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[[Category: Kruse, A C]]
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[[Category: Garcia KC]]
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[[Category: Newell, E W]]
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[[Category: Kruse AC]]
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[[Category: Immune system]]
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[[Category: Newell EW]]
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[[Category: Immunoglobulin domain]]
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[[Category: Mhc molecule]]
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[[Category: T cell receptor]]
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Revision as of 11:47, 14 March 2024

Crystal structure of the 226 TCR in complex with MCC-p5E/I-Ek

PDB ID 3qiw

Drag the structure with the mouse to rotate

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