3qle

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<StructureSection load='3qle' size='340' side='right'caption='[[3qle]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='3qle' size='340' side='right'caption='[[3qle]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qle]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qle]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_EC1118 Saccharomyces cerevisiae EC1118]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.831&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EC1118_1P2_2410g ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=643680 Baker's yeast])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qle OCA], [https://pdbe.org/3qle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qle RCSB], [https://www.ebi.ac.uk/pdbsum/3qle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qle ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qle OCA], [https://pdbe.org/3qle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qle RCSB], [https://www.ebi.ac.uk/pdbsum/3qle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qle ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/C8ZIW7_YEAS8 C8ZIW7_YEAS8]
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Many mitochondrial proteins are synthesized as preproteins carrying amino-terminal presequences in the cytosol. The preproteins are imported by the translocase of the outer mitochondrial membrane and the presequence translocase of the inner membrane. Tim50 and Tim23 transfer preproteins through the intermembrane space to the inner membrane. We report the crystal structure of the intermembrane space domain of yeast Tim50 to 1.83 A resolution. A protruding beta-hairpin of Tim50 is crucial for interaction with Tim23, providing a molecular basis for the cooperation of Tim50 and Tim23 in preprotein translocation to the protein-conducting channel of the mitochondrial inner membrane.
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Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase.,Qian X, Gebert M, Hopker J, Yan M, Li J, Wiedemann N, van der Laan M, Pfanner N, Sha B J Mol Biol. 2011 Jun 17. PMID:21704637<ref>PMID:21704637</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qle" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gebert, M]]
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[[Category: Saccharomyces cerevisiae EC1118]]
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[[Category: Hpker, J]]
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[[Category: Gebert M]]
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[[Category: Laan, M V.D]]
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[[Category: Hpker J]]
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[[Category: Li, J Z]]
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[[Category: Laan MVD]]
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[[Category: Pfanner, N]]
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[[Category: Li JZ]]
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[[Category: Qian, X G]]
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[[Category: Pfanner N]]
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[[Category: Sha, B D]]
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[[Category: Qian XG]]
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[[Category: Wiedemann, N]]
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[[Category: Sha BD]]
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[[Category: Yan, M]]
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[[Category: Wiedemann N]]
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[[Category: Chaperone]]
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[[Category: Yan M]]
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[[Category: Mitochondrion]]
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[[Category: Preprotein translocation]]
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Current revision

Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase

PDB ID 3qle

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