3qmg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:51, 14 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3qmg' size='340' side='right'caption='[[3qmg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3qmg' size='340' side='right'caption='[[3qmg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3qmg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMG FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3qmg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMG FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qmb|3qmb]], [[3qmc|3qmc]], [[3qmd|3qmd]], [[3qmh|3qmh]], [[3qmi|3qmi]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CFP1, CGBP, CXXC1, PCCX1, PHF18 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmg OCA], [https://pdbe.org/3qmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmg RCSB], [https://www.ebi.ac.uk/pdbsum/3qmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmg OCA], [https://pdbe.org/3qmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmg RCSB], [https://www.ebi.ac.uk/pdbsum/3qmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/CXXC1_HUMAN CXXC1_HUMAN]] Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.<ref>PMID:21407193</ref>
+
[https://www.uniprot.org/uniprot/CXXC1_HUMAN CXXC1_HUMAN] Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.<ref>PMID:21407193</ref>
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
CFP1 is a CXXC domain-containing protein and an essential component of the SETD1 histone H3K4 methyltransferase complex. CXXC domain proteins direct different chromatin-modifying activities to various chromatin regions. Here, we report crystal structures of the CFP1 CXXC domain in complex with six different CpG DNA sequences. The crescent-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA. The structures elucidate the molecular mechanism of the non-methylated CpG-binding specificity of the CFP1 CXXC domain. The CpG motif is confined by a tripeptide located in a rigid loop, which only allows the accommodation of the non-methylated CpG dinucleotide. Furthermore, we demonstrate that CFP1 has a preference for a guanosine nucleotide following the CpG motif.
+
-
 
+
-
The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.,Xu C, Bian C, Lam R, Dong A, Min J Nat Commun. 2011 Mar;2:227. PMID:21407193<ref>PMID:21407193</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 3qmg" style="background-color:#fffaf0;"></div>
+
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bian, C]]
+
[[Category: Bian C]]
-
[[Category: Bountra, C]]
+
[[Category: Bountra C]]
-
[[Category: Edwards, A M]]
+
[[Category: Edwards AM]]
-
[[Category: MacKenzie, F]]
+
[[Category: MacKenzie F]]
-
[[Category: Min, J]]
+
[[Category: Min J]]
-
[[Category: Structural genomic]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J]]
+
[[Category: Xu C]]
-
[[Category: Xu, C]]
+
-
[[Category: Dna binding protein-dna complex]]
+
-
[[Category: Protein-dna complex]]
+
-
[[Category: Sgc]]
+

Current revision

Structural Basis of Selective Binding of Non-Methylated CpG islands by the CXXC Domain of CFP1

PDB ID 3qmg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3qmg"
Personal tools