3qnw

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<StructureSection load='3qnw' size='340' side='right'caption='[[3qnw]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='3qnw' size='340' side='right'caption='[[3qnw]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qnw]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QNW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qnw]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QNW FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3p4u|3p4u]], [[3p45|3p45]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6, MCH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnw OCA], [https://pdbe.org/3qnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qnw RCSB], [https://www.ebi.ac.uk/pdbsum/3qnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnw OCA], [https://pdbe.org/3qnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qnw RCSB], [https://www.ebi.ac.uk/pdbsum/3qnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Caspase-6 is a cysteine protease implicated in neuronal survival and apoptosis. Deregulation of caspase-6 activity was linked to several neurodegenerative disorders including Alzheimer's and Huntington's Diseases. Several recent studies on the structure of caspase-6 feature the caspase-6 zymogen, mature apo-caspase-6 as well as the Ac-VEID-CHO peptide complex. All structures share the same typical dimeric caspase conformation. However, mature apo-caspase-6 crystallized at low pH revealed a novel, non-canonical inactive caspase conformation speculated to represent a latent state of the enzyme suitable for the design of allosteric inhibitors. In this treatise we present the structure of caspase-6 in the non-canonical inactive enzyme conformation bound to the irreversible inhibitor Z-VAD-FMK. The complex features a unique peptide binding mode not observed previously.
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Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation.,Muller I, Lamers MB, Ritchie AJ, Dominguez C, Munoz-Sanjuan I, Kiselyov A Bioorg Med Chem Lett. 2011 Sep 15;21(18):5244-7. Epub 2011 Jul 21. PMID:21820899<ref>PMID:21820899</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qnw" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Caspase 3D structures|Caspase 3D structures]]
*[[Caspase 3D structures|Caspase 3D structures]]
*[[Caspase-6 and neurodegeneration|Caspase-6 and neurodegeneration]]
*[[Caspase-6 and neurodegeneration|Caspase-6 and neurodegeneration]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caspase-6]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dominguez, C]]
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[[Category: Synthetic construct]]
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[[Category: Kiselyov, A]]
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[[Category: Dominguez C]]
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[[Category: Lamers, M]]
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[[Category: Kiselyov A]]
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[[Category: Maillard, M]]
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[[Category: Lamers M]]
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[[Category: Mueller, I]]
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[[Category: Maillard M]]
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[[Category: Munoz, I]]
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[[Category: Mueller I]]
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[[Category: Park, H]]
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[[Category: Munoz I]]
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[[Category: Ritchie, A]]
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[[Category: Park H]]
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[[Category: Cysteine protease]]
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[[Category: Ritchie A]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Revision as of 11:52, 14 March 2024

Caspase-6 in complex with Z-VAD-FMK inhibitor

PDB ID 3qnw

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