3quz

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<StructureSection load='3quz' size='340' side='right'caption='[[3quz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3quz' size='340' side='right'caption='[[3quz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3quz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QUZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3quz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QUZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QUV:N-[(2S,3S,4R)-1-({6-DEOXY-6-[(NAPHTHALEN-1-YLCARBAMOYL)AMINO]-ALPHA-D-GALACTOPYRANOSYL}OXY)-3,4-DIHYDROXYOCTADECAN-2-YL]HEXACOSANAMIDE'>QUV</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qux|3qux]], [[3quy|3quy]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QUV:N-[(2S,3S,4R)-1-({6-DEOXY-6-[(NAPHTHALEN-1-YLCARBAMOYL)AMINO]-ALPHA-D-GALACTOPYRANOSYL}OXY)-3,4-DIHYDROXYOCTADECAN-2-YL]HEXACOSANAMIDE'>QUV</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd1.1, CD1d, Cd1d1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m, beta-2-microglobulin, mCG_11606, RP23-34E24.5-001 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3quz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3quz OCA], [https://pdbe.org/3quz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3quz RCSB], [https://www.ebi.ac.uk/pdbsum/3quz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3quz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3quz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3quz OCA], [https://pdbe.org/3quz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3quz RCSB], [https://www.ebi.ac.uk/pdbsum/3quz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3quz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Invariant natural killer T (iNKT) cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. Here, we report the structure and function of a novel class of aromatic alpha-galactosylceramide structurally related glycolipids with marked Th1 bias in both mice and men, leading to superior tumour protection in vivo. The strength of the Th1 response correlates well with enhanced lipid binding to CD1d as a result of an induced fit mechanism that binds the aromatic substitution as a third anchor, in addition to the two lipid chains. This induced fit is in contrast to another Th1-biasing glycolipid, alpha-C-GalCer, whose CD1d binding follows a conventional key-lock principle. These findings highlight the previously unexploited flexibility of CD1d in accommodating galactose-modified glycolipids and broaden the range of glycolipids that can stimulate iNKT cells. We speculate that glycolipids can be designed that induce a similar fit, thereby leading to superior and more sustained iNKT cell responses in vivo.
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Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis.,Aspeslagh S, Li Y, Yu ED, Pauwels N, Trappeniers M, Girardi E, Decruy T, Van Beneden K, Venken K, Drennan M, Leybaert L, Wang J, Franck RW, Van Calenbergh S, Zajonc DM, Elewaut D EMBO J. 2011 Jun 1;30(11):2294-305. Epub 2011 May 6. PMID:21552205<ref>PMID:21552205</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3quz" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Girardi, E]]
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[[Category: Girardi E]]
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[[Category: Li, Y]]
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[[Category: Li Y]]
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[[Category: Yu, E D]]
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[[Category: Yu ED]]
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[[Category: Zajonc, D M]]
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[[Category: Zajonc DM]]
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[[Category: Antigen presentation]]
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[[Category: Glycolipid]]
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[[Category: Immune system]]
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[[Category: Nkt cell]]
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Revision as of 11:59, 14 March 2024

Structure of the mouse CD1d-NU-alpha-GalCer-iNKT TCR complex

PDB ID 3quz

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