3rlz
From Proteopedia
(Difference between revisions)
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<StructureSection load='3rlz' size='340' side='right'caption='[[3rlz]], [[Resolution|resolution]] 2.01Å' scene=''> | <StructureSection load='3rlz' size='340' side='right'caption='[[3rlz]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3rlz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3rlz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RLZ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rlz OCA], [https://pdbe.org/3rlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rlz RCSB], [https://www.ebi.ac.uk/pdbsum/3rlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rlz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rlz OCA], [https://pdbe.org/3rlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rlz RCSB], [https://www.ebi.ac.uk/pdbsum/3rlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rlz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Bos taurus]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liriano | + | [[Category: Liriano MA]] |
| - | [[Category: Weber | + | [[Category: Weber DJ]] |
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Current revision
2.0 Angstrom X-ray structure of bovine Ca(2+)-S100B D63N
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