3rm1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:29, 14 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3rm1' size='340' side='right'caption='[[3rm1]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
<StructureSection load='3rm1' size='340' side='right'caption='[[3rm1]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3rm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RM1 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3rm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RM1 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.24&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rlz|3rlz]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S100B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rm1 OCA], [https://pdbe.org/3rm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rm1 RCSB], [https://www.ebi.ac.uk/pdbsum/3rm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rm1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rm1 OCA], [https://pdbe.org/3rm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rm1 RCSB], [https://www.ebi.ac.uk/pdbsum/3rm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rm1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> [[https://www.uniprot.org/uniprot/CAZA2_BOVIN CAZA2_BOVIN]] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
+
[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
==See Also==
==See Also==
Line 18: Line 17:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bovin]]
+
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Liriano, M A]]
+
[[Category: Liriano MA]]
-
[[Category: Weber, D J]]
+
[[Category: Weber DJ]]
-
[[Category: Alpha-helical]]
+
-
[[Category: Ef hand]]
+
-
[[Category: Metal binding protein-protein binding complex]]
+

Current revision

1.24 Angstrom X-ray structure of bovine TRTK12-Ca(2+)-S100B D63N

PDB ID 3rm1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3rm1"
Personal tools