3rq3
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='3rq3' size='340' side='right'caption='[[3rq3]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='3rq3' size='340' side='right'caption='[[3rq3]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3rq3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3rq3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RQ3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rq3 OCA], [https://pdbe.org/3rq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rq3 RCSB], [https://www.ebi.ac.uk/pdbsum/3rq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rq3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rq3 OCA], [https://pdbe.org/3rq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rq3 RCSB], [https://www.ebi.ac.uk/pdbsum/3rq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rq3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. | |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Almo | + | [[Category: Almo SC]] |
| - | [[Category: Guo | + | [[Category: Guo H]] |
| - | + | [[Category: Nathenson SG]] | |
| - | + | [[Category: Ramagopal UA]] | |
| - | [[Category: Nathenson | + | [[Category: Rubinstein R]] |
| - | [[Category: Ramagopal | + | [[Category: Samanta D]] |
| - | [[Category: Rubinstein | + | |
| - | [[Category: Samanta | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form
| |||||||||||
