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3ruh

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Current revision (12:37, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3ruh' size='340' side='right'caption='[[3ruh]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
<StructureSection load='3ruh' size='340' side='right'caption='[[3ruh]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ruh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"aeromonas_shigelloides"_(bader_1954)_ewing_et_al._1961 "aeromonas shigelloides" (bader 1954) ewing et al. 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RUH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ruh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plesiomonas_shigelloides Plesiomonas shigelloides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RUH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UD6:[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3-(2-oxidanylidenepropyl)oxan-2-yl]+hydrogen+phosphate'>UD6</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ru7|3ru7]], [[3ru9|3ru9]], [[3rua|3rua]], [[3ruc|3ruc]], [[3rud|3rud]], [[3rue|3rue]], [[3ruf|3ruf]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UD6:[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3-(2-oxidanylidenepropyl)oxan-2-yl]+hydrogen+phosphate'>UD6</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">wbgU ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=703 "Aeromonas shigelloides" (Bader 1954) Ewing et al. 1961])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ruh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ruh OCA], [https://pdbe.org/3ruh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ruh RCSB], [https://www.ebi.ac.uk/pdbsum/3ruh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ruh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ruh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ruh OCA], [https://pdbe.org/3ruh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ruh RCSB], [https://www.ebi.ac.uk/pdbsum/3ruh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ruh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNE_PLESH GNE_PLESH] Catalyzes the epimerization of UDP-N-acetylglucosamine (UDP-GlcNAc) to UDP-N-acetylgalactosamine (UDP-GalNAc). Has very low epimerase activity with UDP-Glc and UDP-Gal. Plays a role in the biosynthesis of 2-acetamino-2-deoxy-L-altruronic acid, a building block of the O-antigen in bacterial lipopolysaccharide (LPS).<ref>PMID:12484781</ref> <ref>PMID:21810411</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bhatt, V S]]
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[[Category: Plesiomonas shigelloides]]
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[[Category: Guan, W]]
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[[Category: Bhatt VS]]
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[[Category: Wang, P G]]
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[[Category: Guan W]]
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[[Category: Isomerase]]
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[[Category: Wang PG]]
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[[Category: Rossmann fold]]
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[[Category: Udp-hexose 4-epimerase]]
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Current revision

Alternative analogs as viable substrates of UDP-hexose 4-epimerases

PDB ID 3ruh

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