3sop

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Current revision (13:03, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3sop' size='340' side='right'caption='[[3sop]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
<StructureSection load='3sop' size='340' side='right'caption='[[3sop]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sop]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sop]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.885&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEP3, SEPT3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sop OCA], [https://pdbe.org/3sop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sop RCSB], [https://www.ebi.ac.uk/pdbsum/3sop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sop ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sop OCA], [https://pdbe.org/3sop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sop RCSB], [https://www.ebi.ac.uk/pdbsum/3sop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sop ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SEPT3_HUMAN SEPT3_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
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[https://www.uniprot.org/uniprot/SEPT3_HUMAN SEPT3_HUMAN] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The human genome codes for thirteen members of a family of filament forming GTP-binding proteins known as septins. These have been divided into four different subgroups on the basis of sequence similarity. The differences between the subgroups are believed to control their correct assembly into hetero-filaments which have specific roles in membrane remodeling events. Many different combinations of the 13 proteins are theoretically possible and it is therefore important to understand the structural basis of specific filament assembly. However, three-dimensional structures are currently available for only three of the four subgroups. Here we describe the crystal structure of a construct of human SEPT3 which belongs to the outstanding subgroup. This construct (SEPT3-GC), which includes the GTP-binding and C-terminal domains, purifies as a nucleotide-free monomer readily allowing for its characterization in terms of GTP-binding and hydrolysis. In the crystal, SEPT3-GC forms foreshortened filaments which employ the same NC and G interfaces observed in the hetero-trimeric complex of human septins 2, 6 and 7, reinforcing the notion of 'promiscuous' interactions described previously. Here, we describe these two interfaces and relate the structure to its tendency to form monomers and its efficiency in the hydrolysis of GTP. The relevance of these results is emphasized by the fact that septins from the SEPT3 subgroup may be important determinants of polymerization by occupying the terminal position in octameric units which themselves form the building blocks of at least some hetero-filaments.
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The structure and properties of Septin 3: a possible missing link in septin filament formation.,Macedo JN, Valadares NF, Marques IA, Ferreira FM, Damalio JC, Pereira HM, Garratt RC, Araujo AP Biochem J. 2012 Nov 19. PMID:23163726<ref>PMID:23163726</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3sop" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Araujo, A P.U]]
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[[Category: Araujo APU]]
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[[Category: Garratt, R C]]
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[[Category: Garratt RC]]
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[[Category: Macedo, J N.A]]
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[[Category: Macedo JNA]]
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[[Category: Marques, I A]]
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[[Category: Marques IA]]
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[[Category: Pereira, H M]]
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[[Category: Pereira HM]]
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[[Category: Valadares, N F]]
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[[Category: Valadares NF]]
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[[Category: Hydrolase]]
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Current revision

Crystal Structure Of Human Septin 3 GTPase Domain

PDB ID 3sop

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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