3t4l
From Proteopedia
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<StructureSection load='3t4l' size='340' side='right'caption='[[3t4l]], [[Resolution|resolution]] 1.53Å' scene=''> | <StructureSection load='3t4l' size='340' side='right'caption='[[3t4l]], [[Resolution|resolution]] 1.53Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3t4l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3t4l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T4L FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=ZEA:(2E)-2-METHYL-4-(9H-PURIN-6-YLAMINO)BUT-2-EN-1-OL'>ZEA</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t4l OCA], [https://pdbe.org/3t4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t4l RCSB], [https://www.ebi.ac.uk/pdbsum/3t4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t4l ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t4l OCA], [https://pdbe.org/3t4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t4l RCSB], [https://www.ebi.ac.uk/pdbsum/3t4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t4l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/AHK4_ARATH AHK4_ARATH] Cytokinins (CK) receptor related to bacterial two-component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feed phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. In the absence of cytokinin, removes phosphate from HPt proteins, decreasing the system phosphoload. Involved in meristems establishment in seedlings. Acts as a redundant negative regulator of drought and salt stress responses, and abscisic acid (ABA) signaling in a cytokinin-dependent manner. Required to set vascular asymmetric cell divisions that establish phloem and procambium cell lines. Redundant positive regulator of cytokinin signaling that regulates many development process including seed germination, cell division, seed size, chlorophyll retention during leaf senescence, root repression and shoot promotion. Can interact with isoprenoid-type cytokinins trans-zeatin (tZ and tZR), isopentenyladenine (iP), and isopentenyladenosine (iPR), the meta hydroxylated derivative of benzyladenine m-topolin, buta-2,3-dienyladenine (HA-8), penta-2,3-dienyladenine (HA-1), 4-methyl-penta-2,3-dienyladenine (HA-10), 4-hydroxy-2-butynyladenine (RM1), 2-butynyladenine (RM6), and to a lower extent, with cis-zeatin (cZ), zeatin riboside and dihydrozeatin (DZ). Together with AHK3, involved in the cytokinin-dependent responses to Pi starvation and sucrose stresses. Required for the formation of auxin-transporting vascular tissues in the hypocotyl, and primary and lateral roots, but not in adventitious roots, thus leading to auxin basipetal transport that regulates root development and branching. Involved in alkamides (e.g. N-isobutyl decanamide) and N-acylethanolamides (NAE) signaling that control meristematic activity and differentiation processes during plant development. Prevents the uptake of sulfate by mediating cytokinin-dependent down-regulation of high-affinity sulfate transporters (e.g. SULTR1;1 and SULTR1;2) expression in roots. Together with AHK2, required for growth and reproduction promotion stimulated by the endophytic fungus Piriformospora indica in a trans-zeatin-dependent manner. Required to trigger the phytotoxic effect of the snapdragon (Antirrhinum majus) flowers volatile organic compound (VOC) methyl benzoate (MB). Plays a role in the cytokinin-mediated repression of the iron uptake pathway.<ref>PMID:11114883</ref> <ref>PMID:11234017</ref> <ref>PMID:11230563</ref> <ref>PMID:11479382</ref> <ref>PMID:11577198</ref> <ref>PMID:12354925</ref> <ref>PMID:12410813</ref> <ref>PMID:15155880</ref> <ref>PMID:15509853</ref> <ref>PMID:15053761</ref> <ref>PMID:15144379</ref> <ref>PMID:15166290</ref> <ref>PMID:16246292</ref> <ref>PMID:15923327</ref> <ref>PMID:15728338</ref> <ref>PMID:16753566</ref> <ref>PMID:17075078</ref> <ref>PMID:16361392</ref> <ref>PMID:16357038</ref> <ref>PMID:17216481</ref> <ref>PMID:17956858</ref> <ref>PMID:18077346</ref> <ref>PMID:17965178</ref> <ref>PMID:18571199</ref> <ref>PMID:18785832</ref> <ref>PMID:18397377</ref> <ref>PMID:19032596</ref> <ref>PMID:20110319</ref> | |
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== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Arabidopsis thaliana]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hothorn | + | [[Category: Hothorn M]] |
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Revision as of 13:17, 14 March 2024
Arabidopsis histidine kinase 4 sensor domain in complex with trans-zeatin
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