3t8s

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<StructureSection load='3t8s' size='340' side='right'caption='[[3t8s]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
<StructureSection load='3t8s' size='340' side='right'caption='[[3t8s]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3t8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T8S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3t8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T8S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.77&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Insp3r, Itpr1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t8s OCA], [https://pdbe.org/3t8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t8s RCSB], [https://www.ebi.ac.uk/pdbsum/3t8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t8s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t8s OCA], [https://pdbe.org/3t8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t8s RCSB], [https://www.ebi.ac.uk/pdbsum/3t8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t8s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
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[https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate receptor (InsP(3)R) in its apo and InsP(3)-bound conformations. Comparison of these two conformations reveals that LBD's first beta-trefoil fold (beta-TF1) and armadillo repeat fold (ARF) move together as a unit relative to its second beta-trefoil fold (beta-TF2). Whereas apo LBD may spontaneously transition between gating conformations, InsP(3) binding shifts this equilibrium toward the active state.
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Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor.,Lin CC, Baek K, Lu Z Nat Struct Mol Biol. 2011 Sep 4. doi: 10.1038/nsmb.2112. PMID:21892169<ref>PMID:21892169</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3t8s" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baek, K]]
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[[Category: Rattus norvegicus]]
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[[Category: Lin, C]]
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[[Category: Baek K]]
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[[Category: Lu, Z]]
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[[Category: Lin C]]
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[[Category: Armadillo repeat fold]]
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[[Category: Lu Z]]
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[[Category: Beta-trefoil fold]]
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[[Category: Ca2+ release channel]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Ip3]]
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[[Category: Ligand gated channel]]
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[[Category: Ligand-binding domain]]
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[[Category: Membrane protein]]
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[[Category: Transport protein]]
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Current revision

Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor

PDB ID 3t8s

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