3tbt

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<StructureSection load='3tbt' size='340' side='right'caption='[[3tbt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3tbt' size='340' side='right'caption='[[3tbt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tbt]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tbt]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus_(strain_WE) Lymphocytic choriomeningitis virus (strain WE)] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBT FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[3qul|3qul]], [[3quk|3quk]], [[3tbw|3tbw]], [[3tbx|3tbx]], [[3tby|3tby]], [[3tbz|3tbz]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbt OCA], [https://pdbe.org/3tbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbt RCSB], [https://www.ebi.ac.uk/pdbsum/3tbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbt OCA], [https://pdbe.org/3tbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbt RCSB], [https://www.ebi.ac.uk/pdbsum/3tbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
==See Also==
==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Achour, A]]
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[[Category: Achour A]]
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[[Category: Allerbring, E B]]
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[[Category: Allerbring EB]]
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[[Category: Badia-Martinez, D]]
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[[Category: Badia-Martinez D]]
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[[Category: Duru, A D]]
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[[Category: Duru AD]]
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[[Category: Madhurantakam, C]]
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[[Category: Madhurantakam C]]
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[[Category: Mazumdar, P A]]
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[[Category: Mazumdar PA]]
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[[Category: Nygren, P]]
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[[Category: Nygren P]]
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[[Category: Sandalova, T]]
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[[Category: Sandalova T]]
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[[Category: Uchtenhagen, H]]
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[[Category: Uchtenhagen H]]
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[[Category: Agonism]]
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[[Category: Altered peptide ligand]]
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[[Category: Antagonism]]
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[[Category: Antigen presentation]]
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[[Category: Beta2-microglobulin]]
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[[Category: Cd8]]
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[[Category: Cell surface]]
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[[Category: Immune system]]
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[[Category: Immune system-agonist complex]]
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[[Category: Lcmv]]
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[[Category: Murine mhc]]
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[[Category: Receptor binding]]
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[[Category: T cell receptor]]
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[[Category: T cell recognition]]
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Revision as of 13:23, 14 March 2024

CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P, Y4S)

PDB ID 3tbt

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