3tgh

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Current revision (13:27, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3tgh' size='340' side='right'caption='[[3tgh]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3tgh' size='340' side='right'caption='[[3tgh]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GAP50, PFI0880c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [https://pdbe.org/3tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [https://www.ebi.ac.uk/pdbsum/3tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [https://pdbe.org/3tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [https://www.ebi.ac.uk/pdbsum/3tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgh ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8I2X3_PLAF7 Q8I2X3_PLAF7]
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The glideosome associated protein GAP50 is an essential protein in apicomplexan parasites such as Plasmodium, Toxoplasma and Cryptosporidium, several species of which are important human pathogens. The 44.6kDa protein is part of a multi-protein complex known as the invasion machinery or glideosome, which is required for cell invasion and substrate gliding motility empowered by an actin-myosin motor. GAP50 is anchored through its C-terminal transmembrane helix into the inner membrane complex and interacts via a short six residue C-terminal tail with other proteins of the invasion machinery in the pellicle of the parasite. In this paper we describe the 1.7A resolution crystal structure of the soluble GAP50 domain from the malaria parasite Plasmodium falciparum. The structure shows an alphassssalpha fold with overall similarity to purple acid phosphatases with, however, little homology regarding the nature of the residues in the active site region of the latter enzyme. While purple acid phosphatases contain a phosphate bridged binuclear Fe-site coordinated by seven side chains with the Fe-ions 3.2A apart, GAP50 in our crystals contains two cobalt ions each with one protein ligand and a distance between the Co(2+) ions of 18A.
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Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.,Bosch J, Paige MH, Vaidya AB, Bergman LW, Hol WG J Struct Biol. 2012 Apr;178(1):61-73. Epub 2012 Feb 22. PMID:22387043<ref>PMID:22387043</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3tgh" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acid phosphatase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plaf7]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Bergman, L]]
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[[Category: Bergman L]]
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[[Category: Bosch, J]]
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[[Category: Bosch J]]
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[[Category: Hol, W G.J]]
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[[Category: Hol WGJ]]
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[[Category: Paige, M H]]
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[[Category: Paige MH]]
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[[Category: Vaidya, A]]
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[[Category: Vaidya A]]
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[[Category: Cell invasion]]
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[[Category: Membrane protein]]
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[[Category: Motor protein]]
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[[Category: Not a phosphatase]]
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[[Category: Phosphatase fold]]
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[[Category: Structural protein]]
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Current revision

GAP50 the anchor in the inner membrane complex of Plasmodium

PDB ID 3tgh

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