3uki

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Current revision (14:00, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3uki' size='340' side='right'caption='[[3uki]], [[Resolution|resolution]] 4.15&Aring;' scene=''>
<StructureSection load='3uki' size='340' side='right'caption='[[3uki]], [[Resolution|resolution]] 4.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3uki]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_33277 Atcc 33277]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UKI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3uki]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UKI FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ho7|3ho7]], [[3t22|3t22]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.15&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">oxyR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=837 ATCC 33277])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uki OCA], [https://pdbe.org/3uki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uki RCSB], [https://www.ebi.ac.uk/pdbsum/3uki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uki ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uki OCA], [https://pdbe.org/3uki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uki RCSB], [https://www.ebi.ac.uk/pdbsum/3uki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uki ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q20K61_PORGN Q20K61_PORGN]
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OxyR transcriptionally regulates Escherichia coli oxidative stress response genes through a reversibly reducible cysteine disulfide biosensor of cellular redox status. Structural changes induced by redox changes in these cysteines are conformationally transmitted to the dimer subunit interfaces, which alters dimer and tetramer interactions with DNA. In contrast to E. coli OxyR regulatory-domain structures, crystal structures of Porphyromonas gingivalis OxyR regulatory domains show minimal differences in dimer configuration on changes in cysteine disulfide redox status. This locked configuration of the P. gingivalis OxyR regulatory-domain dimer closely resembles the oxidized (activating) form of the E. coli OxyR regulatory-domain dimer. It correlates with the observed constitutive activation of some oxidative stress genes in P. gingivalis and is attributable to a single amino-acid insertion in P. gingivalis OxyR relative to E. coli OxyR. Modelling of full-length P. gingivalis, E. coli and Neisseria meningitidis OxyR-DNA complexes predicts different modes of DNA binding for the reduced and oxidized forms of each.
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Structures of the Porphyromonas gingivalis OxyR regulatory domain explain differences in expression of the OxyR regulon in Escherichia coli and P. gingivalis.,Svintradze DV, Peterson DL, Collazo-Santiago EA, Lewis JP, Wright HT Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2091-103. doi:, 10.1107/S0907444913019471. Epub 2013 Sep 20. PMID:24100327<ref>PMID:24100327</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3uki" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 33277]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Collazo-Santiago, E A]]
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[[Category: Porphyromonas gingivalis]]
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[[Category: Lewis, J P]]
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[[Category: Collazo-Santiago EA]]
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[[Category: Svintradze, D V]]
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[[Category: Lewis JP]]
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[[Category: Wright, H T]]
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[[Category: Svintradze DV]]
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[[Category: Beta-alpha-barrel]]
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[[Category: Wright HT]]
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[[Category: Dna-binding]]
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[[Category: Redox-sensitive transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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Current revision

Crystal structure of reduced OxyR from Porphyromonas gingivalis

PDB ID 3uki

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