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3umf

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Current revision (14:01, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3umf' size='340' side='right'caption='[[3umf]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='3umf' size='340' side='right'caption='[[3umf]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3umf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UMF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3umf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UMF FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Smp_071390 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.047&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3umf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3umf OCA], [https://pdbe.org/3umf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3umf RCSB], [https://www.ebi.ac.uk/pdbsum/3umf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3umf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3umf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3umf OCA], [https://pdbe.org/3umf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3umf RCSB], [https://www.ebi.ac.uk/pdbsum/3umf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3umf ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G4V9S0_SCHMA G4V9S0_SCHMA]
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The human parasite Schistosoma mansoni is totally dependent on the purine salvage pathway in order to supply large quantities of purine precursors for its energy and DNA biosynthetic needs. Adenylate kinase (ADK) is responsible for the conversion of AMP (produced by the adenosine kinase reaction) into ADP, which is subsequently converted into ATP by nucleoside diphosphate kinase (NDPK). ADK and NDPK are the most active enzymes of the pathway, probably reflecting an evolutionary adaptation due to the intense use of the branch in which they participate. However, notwithstanding their importance very little information has been accumulated found regarding these enzymes. In this work two adenylate kinases from S. mansoni were cloned and heterologously expressed in Escherichia coli. The purified products were utilized in activity assays, and displayed kinetic parameters similar to the corresponding human orthologous proteins. The cytosolic S. mansoni ADK was crystallized and its structure solved allowing us to detect a difference in the nucleotide binding site when compared with the human ortholog.
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Structural and kinetic studies of Schistosoma mansoni adenylate kinases.,Marques ID, Romanello L, Demarco R, Pereira HD Mol Biochem Parasitol. 2012 Jul 26. PMID:22841753<ref>PMID:22841753</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3umf" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenylate kinase]]
 
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[[Category: Blood fluke]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: DeMarco, R]]
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[[Category: Schistosoma mansoni]]
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[[Category: Marques, I]]
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[[Category: DeMarco R]]
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[[Category: Pereira, H M]]
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[[Category: Marques I]]
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[[Category: Rossmann fold]]
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[[Category: Pereira HM]]
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[[Category: Transferase]]
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Current revision

Schistosoma mansoni adenylate kinase

PDB ID 3umf

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