3v06
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3v06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V06 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3v06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V06 FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F5H:3,7-ANHYDRO-1,5,6-TRIDEOXY-5-FLUORO-6-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-2-O-PHOSPHONO-D-GLYCERO-L-ALTRO-HEPTITOL'>F5H</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v06 OCA], [https://pdbe.org/3v06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v06 RCSB], [https://www.ebi.ac.uk/pdbsum/3v06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v06 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v06 OCA], [https://pdbe.org/3v06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v06 RCSB], [https://www.ebi.ac.uk/pdbsum/3v06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v06 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Locked nucleic acid (LNA) analogues with 2',4'-bridged sugars show promise in antisense applications. S-5'-Me-LNA has high RNA affinity, and modified oligonucleotides show weakened immune stimulation in vivo. Conversely, an R-5'-methyl group dramatically lowers RNA affinity. To test the effects of S- and R-6'-methyl groups on 3'-fluoro hexitol nucleic acid (FHNA) stability, we synthesized S- and R-6'-Me-FHNA thymidine and incorporated them into oligo-2'-deoxynucleotides. As with LNA, S-6'-Me is stabilizing whereas R-6'-Me is destabilizing. Crystal structures of 6'-Me-FHNA-modified DNAs explain the divergent consequences for stability and suggest convergent origins of these effects by S- and R-6'-Me (FHNA) [-5'-Me (LNA and RNA)] substituents. | ||
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| - | Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.,Pallan PS, Yu J, Allerson CR, Swayze EE, Seth P, Egli M Biochemistry. 2012 Jan 10;51(1):7-9. Epub 2011 Dec 29. PMID:22229409<ref>PMID:22229409</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 3v06" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Egli | + | [[Category: Egli M]] |
| - | [[Category: Pallan | + | [[Category: Pallan PS]] |
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Current revision
Crystal structure of S-6'-Me-3'-fluoro hexitol nucleic acid
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