4duh
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4duh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DUH FirstGlance]. <br> | <table><tr><td colspan='2'>[[4duh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DUH FirstGlance]. <br> | ||
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RLI:4-{[4-METHYL-2-(PROPANOYLAMINO)-4,5-BI-1,3-THIAZOL-2-YL]AMINO}BENZOIC+ACID'>RLI</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RLI:4-{[4-METHYL-2-(PROPANOYLAMINO)-4,5-BI-1,3-THIAZOL-2-YL]AMINO}BENZOIC+ACID'>RLI</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4duh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4duh OCA], [https://pdbe.org/4duh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4duh RCSB], [https://www.ebi.ac.uk/pdbsum/4duh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4duh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4duh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4duh OCA], [https://pdbe.org/4duh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4duh RCSB], [https://www.ebi.ac.uk/pdbsum/4duh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4duh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | + | [https://www.uniprot.org/uniprot/GYRB_ECOLI GYRB_ECOLI] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.<ref>PMID:12051843</ref> <ref>PMID:18642932</ref> <ref>PMID:20675723</ref> | |
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==See Also== | ==See Also== |
Current revision
Crystal structure of 24 kDa domain of E. coli DNA gyrase B in complex with small molecule inhibitor
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