4ep0

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ep0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_virus_C1 Streptococcus virus C1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EP0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ep0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_virus_C1 Streptococcus virus C1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EP0 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ep0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ep0 OCA], [https://pdbe.org/4ep0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ep0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ep0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ep0 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ep0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ep0 OCA], [https://pdbe.org/4ep0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ep0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ep0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ep0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Q7Y3F0_9CAUD Q7Y3F0_9CAUD]]
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[https://www.uniprot.org/uniprot/Q7Y3F0_9CAUD Q7Y3F0_9CAUD]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Podoviridae phage C1 was one of the earliest isolated bacteriophages and the first virus documented to be active against streptococci. The icosahedral and asymmetric reconstructions of the virus were calculated using cryo-electron microscopy. The capsid protein has an HK97 fold arranged into a T = 4 icosahedral lattice. The C1 tail is terminated with a varphi29-like knob, surrounded by a skirt of twelve long appendages with novel morphology. Several C1 structural proteins have been identified, including a candidate for an appendage. The crystal structure of the knob has an N-terminal domain with a fold observed previously in tube forming proteins of Siphoviridae and Myoviridae phages. The structure of C1 suggests the mechanisms by which the virus digests the cell wall and ejects its genome. Although there is little sequence similarity to other phages, conservation of the structural proteins demonstrates a common origin of the head and tail, but more recent evolution of the appendages.
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Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry.,Aksyuk AA, Bowman VD, Kaufmann B, Fields C, Klose T, Holdaway HA, Fischetti VA, Rossmann MG Proc Natl Acad Sci U S A. 2012 Aug 13. PMID:22891295<ref>PMID:22891295</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ep0" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>

Current revision

Structure of the bacteriophage C1 tail knob protein, gp12

PDB ID 4ep0

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OCA

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