1r4r

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[[Image:1r4r.gif|left|200px]]
[[Image:1r4r.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1r4r |SIZE=350|CAPTION= <scene name='initialview01'>1r4r</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1r4r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NR3C1 OR GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_1r4r| PDB=1r4r | SCENE= }}
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|RELATEDENTRY=[[1glu|1GLU]], [[1r4o|1R4O]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r4r OCA], [http://www.ebi.ac.uk/pdbsum/1r4r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r4r RCSB]</span>
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}}
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'''Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA'''
'''Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA'''
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[[Category: Xu, W X.]]
[[Category: Xu, W X.]]
[[Category: Yamamoto, K R.]]
[[Category: Yamamoto, K R.]]
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[[Category: glucocorticoid]]
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[[Category: Glucocorticoid]]
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[[Category: gr]]
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[[Category: Gr]]
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[[Category: ir3]]
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[[Category: Ir3]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: steroid receptor]]
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[[Category: Steroid receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:04:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:23:12 2008''
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Revision as of 04:04, 3 May 2008

Image:1r4r.gif

Template:STRUCTURE 1r4r

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA


Overview

Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation and function. When it binds DNA, the domain dimerizes, placing the subunits in adjacent major grooves. In one complex, the DNA has the symmetrical consensus target sequence; in the second, the central spacing between the target's half-sites is larger by one base pair. This results in one subunit interacting specifically with the consensus target half-site and the other nonspecifically with a noncognate element. The DNA-induced dimer fixes the separation of the subunits' recognition surfaces so that the spacing between the half-sites becomes a critical feature of the target sequence's identity.

About this Structure

1R4R is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA., Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB, Nature. 1991 Aug 8;352(6335):497-505. PMID:1865905 Page seeded by OCA on Sat May 3 07:04:22 2008

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