1r4u

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[[Image:1r4u.gif|left|200px]]
[[Image:1r4u.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1r4u |SIZE=350|CAPTION= <scene name='initialview01'>1r4u</scene>, resolution 1.65&Aring;
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The line below this paragraph, containing "STRUCTURE_1r4u", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=OXC:OXONIC+ACID'>OXC</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1r4u| PDB=1r4u | SCENE= }}
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|RELATEDENTRY=[[1r4s|1R4S]], [[1r51|1R51]], [[1r56|1R56]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r4u OCA], [http://www.ebi.ac.uk/pdbsum/1r4u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r4u RCSB]</span>
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}}
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'''URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR OXONIC ACID'''
'''URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR OXONIC ACID'''
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[[Category: Prange, T.]]
[[Category: Prange, T.]]
[[Category: Retailleau, P.]]
[[Category: Retailleau, P.]]
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[[Category: dimeric barrel]]
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[[Category: Dimeric barrel]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: tunnel-shaped protein]]
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[[Category: Tunnel-shaped protein]]
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[[Category: uric acid degradation]]
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[[Category: Uric acid degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:04:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:23:18 2008''
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Revision as of 04:04, 3 May 2008

Image:1r4u.gif

Template:STRUCTURE 1r4u

URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR OXONIC ACID


Overview

High-resolution X-ray structures of the complexes of Aspergillus flavus urate oxidase (Uox) with three inhibitors, 8-azaxanthin (AZA), 9-methyl uric acid (MUA) and oxonic acid (OXC), were determined in an orthorhombic space group (I222). In addition, the ligand-free enzyme was also crystallized in a monoclinic form (P2(1)) and its structure determined. Higher accuracy in the three new enzyme-inhibitor complex structures (Uox-AZA, Uox-MUA and Uox-OXC) with respect to the previously determined structure of Uox-AZA (PDB code 1uox) leads to a reversed position of the inhibitor in the active site of the enzyme. The corrected anchoring of the substrate (uric acid) allows an improvement in the understanding of the enzymatic mechanism of urate oxidase.

About this Structure

1R4U is a Single protein structure of sequence from Aspergillus flavus. Full crystallographic information is available from OCA.

Reference

Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode., Retailleau P, Colloc'h N, Vivares D, Bonnete F, Castro B, El-Hajji M, Mornon JP, Monard G, Prange T, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):453-62. Epub 2004, Feb 25. PMID:14993669 Page seeded by OCA on Sat May 3 07:04:35 2008

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