1r54

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[[Image:1r54.jpg|left|200px]]
[[Image:1r54.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1r54 |SIZE=350|CAPTION= <scene name='initialview01'>1r54</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1r54", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= ADAM33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1r54| PDB=1r54 | SCENE= }}
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|RELATEDENTRY=[[1r55|1R55]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r54 OCA], [http://www.ebi.ac.uk/pdbsum/1r54 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r54 RCSB]</span>
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}}
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'''Crystal structure of the catalytic domain of human ADAM33'''
'''Crystal structure of the catalytic domain of human ADAM33'''
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[[Category: Yarosh-Tomaine, T.]]
[[Category: Yarosh-Tomaine, T.]]
[[Category: Zou, J.]]
[[Category: Zou, J.]]
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[[Category: adam]]
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[[Category: Adam]]
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[[Category: asthma]]
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[[Category: Asthma]]
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[[Category: metalloprotease]]
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[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:05:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:23:25 2008''
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Revision as of 04:05, 3 May 2008

Image:1r54.jpg

Template:STRUCTURE 1r54

Crystal structure of the catalytic domain of human ADAM33


Overview

Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.

About this Structure

1R54 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745 Page seeded by OCA on Sat May 3 07:05:23 2008

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OCA

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