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1r5i

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5i OCA], [http://www.ebi.ac.uk/pdbsum/1r5i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r5i RCSB]</span>
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'''Crystal structure of the MAM-MHC complex'''
'''Crystal structure of the MAM-MHC complex'''
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[[Category: Mourad, W.]]
[[Category: Mourad, W.]]
[[Category: Zhao, Y.]]
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[[Category: mam]]
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[[Category: Mam]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: superantigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:06:23 2008''
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Revision as of 04:06, 3 May 2008

Image:1r5i.gif

Template:STRUCTURE 1r5i

Crystal structure of the MAM-MHC complex


Overview

Mycoplasma arthritidis-derived mitogen (MAM) is a superantigen that can activate large fractions of T cells bearing particular TCR Vbeta elements. Here we report the crystal structure of MAM complexed with a major histocompatibility complex (MHC) antigen, HLA-DR1, loaded with haemagglutinin peptide 306-318 (HA). The structure reveals that MAM has a novel fold composed of two alpha-helical domains. This fold is entirely different from that of the pyrogenic superantigens, consisting of a beta-grasped motif and a beta barrel. In the complex, the N-terminal domain of MAM binds orthogonally to the MHC alpha1 domain and the bound HA peptide, and to a lesser extent to the MHC beta1 domain. Two MAM molecules form an asymmetric dimer and cross-link two MHC antigens to form a plausible, dimerized MAM-MHC complex. These data provide the first crystallographic evidence that superantigens can dimerize MHC molecules. Based on our structure, a model of the TCR2MAM2MHC2 complex is proposed.

About this Structure

1R5I is a Protein complex structure of sequences from Homo sapiens and Mycoplasma arthritidis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex., Zhao Y, Li Z, Drozd SJ, Guo Y, Mourad W, Li H, Structure. 2004 Feb;12(2):277-88. PMID:14962388 Page seeded by OCA on Sat May 3 07:06:23 2008

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