8gkf

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m (Protected "8gkf" [edit=sysop:move=sysop])
Current revision (08:17, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8gkf is ON HOLD until Paper Publication
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==Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.==
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<StructureSection load='8gkf' size='340' side='right'caption='[[8gkf]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors: Krieger, I.V., Singh, A., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gkf]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GKF FirstGlance]. <br>
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Description: Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D16:TOMUDEX'>D16</scene></td></tr>
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[[Category: Sacchettini, J.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gkf OCA], [https://pdbe.org/8gkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gkf RCSB], [https://www.ebi.ac.uk/pdbsum/8gkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gkf ProSAT]</span></td></tr>
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[[Category: Krieger, I.V]]
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</table>
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[[Category: Singh, A]]
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== Function ==
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[[Category: Tb Structural Genomics Consortium (Tbsgc)]]
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[https://www.uniprot.org/uniprot/PPTT_MYCTU PPTT_MYCTU] Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (PubMed:9831524, PubMed:16709676, PubMed:25785780, PubMed:28203522). Involved in post-translational modification of various type-I polyketide synthases required for the formation of both mycolic acids and lipid virulence factors (PubMed:16709676). Acts on Pks13, Mas, PpsA, PpsB, PpsC and PpsD (PubMed:16709676, PubMed:28203522). Also acts on AcpM, the meromycolate extension acyl carrier protein (PubMed:25785780). In addition, is involved in the activation of the acyl carrier protein MbtL and the nonribosomal peptides synthases MbtB and MbtE, which are involved in the biosynthesis of the siderophore mycobactin (PubMed:9831524, PubMed:28203522).<ref>PMID:16709676</ref> <ref>PMID:25785780</ref> <ref>PMID:28203522</ref> <ref>PMID:9831524</ref> Required for the replication and survival of Mycobacterium during the acute and chronic phases of infection in mice.<ref>PMID:23308068</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Krieger IV]]
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[[Category: Sacchettini JC]]
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[[Category: Singh A]]

Current revision

Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.

PDB ID 8gkf

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