8p0w

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'''Unreleased structure'''
 
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The entry 8p0w is ON HOLD until Paper Publication
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==Structure of the human Commander complex COMMD ring==
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<StructureSection load='8p0w' size='340' side='right'caption='[[8p0w]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Kumpula, E.P., Laulumaa, S., Huiskonen, J.T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p0w]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P0W FirstGlance]. <br>
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Description: Structure of the human Commander complex COMMD ring
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p0w OCA], [https://pdbe.org/8p0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p0w RCSB], [https://www.ebi.ac.uk/pdbsum/8p0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p0w ProSAT]</span></td></tr>
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[[Category: Kumpula, E.P]]
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</table>
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[[Category: Laulumaa, S]]
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== Function ==
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[[Category: Huiskonen, J.T]]
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[https://www.uniprot.org/uniprot/COMD1_HUMAN COMD1_HUMAN] Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.<ref>PMID:14685266</ref> <ref>PMID:15799966</ref> <ref>PMID:16573520</ref> <ref>PMID:17309234</ref> <ref>PMID:17183367</ref> <ref>PMID:20048074</ref> <ref>PMID:20595380</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huiskonen JT]]
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[[Category: Kumpula EP]]
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[[Category: Laulumaa S]]

Revision as of 08:19, 20 March 2024

Structure of the human Commander complex COMMD ring

PDB ID 8p0w

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