8p0x

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'''Unreleased structure'''
 
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The entry 8p0x is ON HOLD until Paper Publication
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==Structure of the human Commander complex Retriever Subcomplex==
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<StructureSection load='8p0x' size='340' side='right'caption='[[8p0x]], [[Resolution|resolution]] 7.50&Aring;' scene=''>
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Authors: Kumpula, E.P., Laulumaa, S., Huiskonen, J.T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p0x]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P0X FirstGlance]. <br>
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Description: Structure of the human Commander complex Retriever Subcomplex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p0x OCA], [https://pdbe.org/8p0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p0x RCSB], [https://www.ebi.ac.uk/pdbsum/8p0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p0x ProSAT]</span></td></tr>
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[[Category: Kumpula, E.P]]
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</table>
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[[Category: Laulumaa, S]]
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== Function ==
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[[Category: Huiskonen, J.T]]
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[https://www.uniprot.org/uniprot/CCD93_HUMAN CCD93_HUMAN] Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947).<ref>PMID:25355947</ref> <ref>PMID:28892079</ref> (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.<ref>PMID:28892079</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huiskonen JT]]
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[[Category: Kumpula EP]]
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[[Category: Laulumaa S]]

Revision as of 08:19, 20 March 2024

Structure of the human Commander complex Retriever Subcomplex

PDB ID 8p0x

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