8p6w

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'''Unreleased structure'''
 
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The entry 8p6w is ON HOLD until Paper Publication
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==Cryo-EM structure of CAK in complex with inhibitor BS-181==
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<StructureSection load='8p6w' size='340' side='right'caption='[[8p6w]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p6w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P6W FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=X2H:~{N}5-(6-azanylhexyl)-~{N}7-(phenylmethyl)-3-propan-2-yl-pyrazolo[1,5-a]pyrimidine-5,7-diamine'>X2H</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p6w OCA], [https://pdbe.org/8p6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p6w RCSB], [https://www.ebi.ac.uk/pdbsum/8p6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p6w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ali S]]
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[[Category: Bahl AK]]
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[[Category: Cushing VI]]
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[[Category: Feng J]]
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[[Category: Greber BJ]]
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[[Category: Jurgaityte K]]
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[[Category: Koh AF]]
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[[Category: Kotecha A]]

Revision as of 08:19, 20 March 2024

Cryo-EM structure of CAK in complex with inhibitor BS-181

PDB ID 8p6w

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