8p71

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:19, 20 March 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8p71 is ON HOLD until Paper Publication
+
==Cryo-EM structure of CAK in complex with inhibitor ICEC0574==
-
 
+
<StructureSection load='8p71' size='340' side='right'caption='[[8p71]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8p71]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P71 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=X4F:(3R,4S)-4-[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]pyrrolidin-3-ol'>X4F</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p71 OCA], [https://pdbe.org/8p71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p71 RCSB], [https://www.ebi.ac.uk/pdbsum/8p71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p71 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Ali S]]
 +
[[Category: Bahl AK]]
 +
[[Category: Cushing VI]]
 +
[[Category: Feng J]]
 +
[[Category: Greber BJ]]
 +
[[Category: Jurgaityte K]]
 +
[[Category: Koh AF]]
 +
[[Category: Kotecha A]]

Current revision

Cryo-EM structure of CAK in complex with inhibitor ICEC0574

PDB ID 8p71

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8p71"
Personal tools