8p79

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'''Unreleased structure'''
 
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The entry 8p79 is ON HOLD until Paper Publication
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==Cryo-EM structure of CAK with averaged inhibitor density==
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<StructureSection load='8p79' size='340' side='right'caption='[[8p79]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p79]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P79 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p79 OCA], [https://pdbe.org/8p79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p79 RCSB], [https://www.ebi.ac.uk/pdbsum/8p79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p79 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCNH_HUMAN CCNH_HUMAN] Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.<ref>PMID:7533895</ref> <ref>PMID:10024882</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ali S]]
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[[Category: Bahl AK]]
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[[Category: Cushing VI]]
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[[Category: Feng J]]
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[[Category: Greber BJ]]
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[[Category: Jurgaityte K]]
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[[Category: Koh AF]]
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[[Category: Kotecha A]]

Revision as of 08:19, 20 March 2024

Cryo-EM structure of CAK with averaged inhibitor density

PDB ID 8p79

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OCA

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